The way you want to use hyaluronic acid in a skincare routine is to start by cleansing your face with a nice simple cleanser. And then, with slightly damp skin or even slightly wet skin, apply the hyaluronic acid serum to your face followed by a moisturizer and sunscreen (during the day). As long as you have the serum sandwiched between slightly damp skin and a moisturizer, you're good to go. It really plumps up the skin and makes it look nice and moisturized, and stays moisturized, throughout the day.